Author

J. Sluijter

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Open access Sep 2026

YTHDF1-mediated m6A RNA regulation controls cardiomyocyte remodeling through KLF11-HIF1α.

Cardiovascular disease remains the leading cause of mortality globally. Although cardiac hypertrophy initially serves as a compensatory adaptation to stress, physiological and pathological hypertrophy are governed by distinct mechanisms and lead to divergent outcomes. However, how cardiomyocytes differentially respond...

Lijun Wang, Jiaqi Wang, Xinxin Cui et al. · Proceedings of the National... · 0 citations

Open access Sep 2026

Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model

The study describes the generation of a humanized pig model carrying an inducible phospholamban R14del mutation for cardiomyopathy modeling and demonstrates Cre-based activation strategies as efficient alternatives to germline Cre-driver lines in large animals.

Petra Runa-Vochozkova, M. Vaškovičová, J. Cambra et al. · Lab animal · 0 citations