Open access
Oct 2026
Nuclear cathepsin L induces DNA damage by regulating DNA repair factors in ovarian cancer.
Resistance to PARP inhibitors (PARPi) remains a major clinical challenge in ovarian cancer (OC), emphasizing the need for novel strategies to enhance therapeutic efficiency. Our previous work revealed that the antimalarial drug quinacrine (QC) can be repurposed to induce cell death in OC by promoting lysosomal release...
P. Thirusangu, Upasana Ray, Ling Jin et al.
· Oncogene · 0 citations