Atrial remodeling of excitation and Ca2+ handling in male mice with cardiac steatosis induced by perilipin 2 overexpression.
BACKGROUND Diabetes mellitus and obesity are major risk factors for atrial fibrillation (AF). Cardiac steatosis, characterized by excessive lipid droplet (LD) accumulation within cardiomyocytes, is frequently observed in these conditions. However, whether myocardial LD accumulation per se directly promotes atrial proar...