Author

J. Swen

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Open access Sep 2026

DPYD c.85T>C, DPYD c.496A>G, and DPYD c.2194G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.

Current DPYD genotyping panels used to prevent fluoropyrimidine (FL)-related toxicity explain only a limited proportion of severe adverse events. The clinical relevance, beyond current testing, of additional DPYD variants, including DPYD⁎6 (c.2194G>A, rs1801160), DPYD c.496A>G (rs2297595), and DPYD⁎9A (c.85T>C, rs18012...

E. De Mattia, J. Polesel, M. van der Lee et al. · Pharmacological Research · 0 citations

Open access Oct 2026

The SafePolyMed Medication Management Center

Abstract Polypharmacy is a major risk factor for adverse drug events (ADEs), particularly when drug-drug and drug- gene interactions are insufficiently considered in routine care. The EU-funded SafePolyMed project addresses this challenge by developing a digital Medication Management Center (MMC) that integrates pharma...

Sabine C. Gepp, F. Schera, F. Marok et al. · Current Directions in Biomed... · 0 citations