Preprint
Aug 2026
Strategy-first synthesis planning for complex natural products
The total synthesis of a complex molecule is among the most demanding intellectual and experimental feats in chemistry: a chemist must plan many steps ahead for how to assemble simple building blocks into an intricate target, devise backup strategies, and anticipate procedural challenges. It is also a profoundly creati...
Daniel P. Armstrong, X. Nguyen, Octavian Susanu et al.
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