Author

J. Tainer

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Aug 2026

Dual MYC and GSPT1 Protein Degrader for MYC-Driven Hematologic Malignancies.

Direct targeting of the oncoprotein MYC has not yet been successful. We here report a novel dual protein degrader, GT19630, which binds directly to MYC and G1 to S phase transition protein 1 (GSPT1). GT19630 disrupts a novel feedforward loop of MYC and GSPT1, where MYC promotes transcription of GSPT1, and GSPT1 senses...

Yuki Nishida, Valeria Impedovo, Edward Ayoub et al. · Blood · 0 citations

Review Open access Sep 2026

Exploiting DNA damage tolerance for precision oncology.

Unresolved DNA lesions trigger replication stress, forcing cancer cells to hijack DNA damage tolerance (DDT) networks, specifically translesion synthesis (TLS) and template switching, to sustain replication. While DDT prevents lethal fork collapse, error-prone TLS drives mutagenesis, tumor evolution, chemoresistance an...

Audesh Bhat, G. Lahane, R. Pandita et al. · Trends in Cancer · 0 citations