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Author

J. van der Oost

2 papers indexed here

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Open access Jul 2026

Systematic engineering and machine learning analysis of intrinsic terminators reveal crucial nucleotides directly upstream of the terminator hairpin

This study showed that an additional adenosine nucleotide upstream of the terminator hairpin leads to improved protein production while reducing terminator read-through, revealing an important role for the nucleotides directly upstream of the terminator hairpin.

Charlotte C. Koster, B. Terlouw, Thijs Nieuwkoop et al. · 0 citations
Open access Aug 2026

Elucidating biosynthetic pathways related to the synthesis of small halogenated peptidic natural products in marine sponge microbiomes

The present work queried metagenomes of several sponge species by making use of a minimal set of core enzymes that postulate to be necessary to produce small peptidic NPs, revealing a variety of novel BGC architectures, many of which showed conservation among sponge host phylogenies and were encoded in the genomes of diverse sponge-associated bacteria.

Catarina Loureiro, M. Schorn, Mohammad M. Alanjary et al. · 0 citations

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