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Author

J. van Noort

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Open access Aug 2026

Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility

Chromatin must fold tightly enough to protect the genome while being sufficiently accessible for DNA dependent processes such as transcription. The physical rules that balance these competing roles remain unclear, as DNA sequence encodes both biochemical information such as transcription factor binding sites, and bioph...

Waad Albawardi, Matthew Thomas, Gert-Jan Kuijntjes et al. · 0 citations
Open access Aug 2026

Mixing chromatin fibers with different nucleosome repeat lengths changes dynamics of chromatin phase separation

The eukaryotic genome is organized into chromatin at multiple lengths and timescales. Liquid-liquid phase separation has recently emerged as a mechanism for the dynamic compartmentalization of chromatin. However, it remains unclear how cells can locally alter phase separation behavior to condense, decondense, and segre...

Jeremy Ernst, Beatriz Orozco Monroy, J. van Noort · 0 citations

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