Evaluation of Dihydropyridine Derivatives as Aldose Reductase Inhibitors: Enzymatic Screening, Molecular Docking and Ex Vivo Assessment of a Selected Compound in a Lens Model
Aldose reductase (AR) is a key enzyme in the polyol pathway and has been widely implicated in the development of diabetic complications, including cataract formation. In this work, a series of structurally modified 1,4-dihydropyridine (DHP) derivatives were evaluated as potential AR inhibitors. The compounds were obtai...