PYGO2 Ablation Promotes Lymphoid Organization and STING-Dependent Antitumor Immunity in Prostate Cancer.
Prostate cancer is an immunologically cold tumor with a limited response to immune checkpoint blockade. Although tertiary lymphoid structures (TLSs) are associated with favorable immunotherapeutic outcomes in various malignancies, the tumor-intrinsic mechanisms governing their formation in prostate cancer remain poorly...