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Review Open access Oct 2026

Antibiotics and outcomes of cancer immunotherapy: An updated meta-analysis and clinical applications.

The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors (ICI), positioning antibiotic exposure as a critical yet under-recognized risk factor for worse survival outcomes in immuno-oncology. As nearly 30% of ICI-treated patients receive antibiotics and indications of cancer immunothera...

Serena Porcari, L. Bolte, J. Björk et al. · 0 citations
Open access Oct 2026

Neoadjuvant pepinemab in combination with nivolumab and/or ipilimumab in resectable metastatic melanoma: a pilot biomarker-driven trial

The trial met its primary endpoint, as enrichment of transcripts associated with activated dendritic cells and immune recruitment pathways was observed in tumors from patients receiving pepinemab-containing regimens, and immune remodeling was evident by formation of mature lymphoid aggregates resembling tertiary lympho...

A. Ruffin, C. Mallow, B. Olson et al. · 0 citations

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