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J. Wikstrom

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Open access Oct 2026

Apolipoprotein and inflammatory biomarker changes following marked triglyceride reduction with the GalNAc-conjugated APOC3 siRNA RBD5044

RBD5044, a GalNAc-conjugated small interfering RNA (siRNA) targeting APOC3, demonstrated robust lipid-lowering efficacy in a Phase I clinical trial. It achieved a 70% reduction in plasma triglyceride (TG) levels, with over 50% reduction maintained at six months. Elevated apoC-III concentrations have previously be...

S. Nilsson, S. Ueckert, A. Gabrielsen et al. · 0 citations

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