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Open access Sep 2026

Clinical outcomes of radiation therapy as an alternative to radical surgery for early-stage rectal cancer

Purpose Total mesorectal excision (TME) is the standard treatment for early rectal cancer, but radiation therapy (RT) with or without chemotherapy may be considered as an alternative organ-preserving option. This study evaluated the oncologic outcomes, patterns of failure, salvage treatment efficacy, and TME–free survi...

Seo Jin Lee, H. K. Byun, Jee-Suk Chang et al. · 0 citations
Open access Aug 2026

Colon-targeted oral delivery of melatonin for regulating macrophage activity and intestinal barrier in ulcerative colitis

Background Despite its promising therapeutic potential, inefficient site-specific targeting and complex fabrication processes hinder the clinical translation of oral melatonin therapy for ulcerative colitis (UC). Herein, we present Melatonin-Eudragit-Thioketal polymer-based Assembly (META), a dual pH/ROS-responsive ora...

Nhu-Nam Nguyen, Yoojin Seo, T. Nguyen et al. · 0 citations

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