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ARID1A Mediates ROS-Induced Osteoclast Activation in TMJ Osteoarthritis.
Excessive osteoclast activation drives rapid subchondral bone destruction, serving as a critical early-stage event precipitating temporomandibular joint osteoarthritis (TMJ-OA). Although epigenetic remodeling is widely recognized as an important interface between pathological environmental signals and genomic response,...