TFIID is instrumental in recognizing promoter sequences and initiating transcription, yet a cohesive understanding of how this complex engages and functions at different promoter types in vivo is still lacking. Here, we employed ChIP-nexus to capture high-resolution binding footprints of all
Drosophila
TFIID subu...
Sergio G.-M. Alcantara, Simon Bourdareau, Melanie Weilert et al.· Nature Communications· 0 citations
A central question in neurobiology is how the transient programs that pattern neural progenitors are translated into the enormous, stable diversity of neuronal types. Spatial and temporal cues act only briefly, yet each neuron’s identity is defined and maintained for life by terminal selector transcription factors (TFs...
R. Coyne, Fahad Kamulegeya, C. Lake et al.· bioRxiv· 1 citation
A major challenge in genomics is deciphering the functional consequences of non-coding genetic variation. Here we present AlphaGenome Atlas, a comprehensive resource that enables the joint interpretation and prioritization of variant effects across the entire human genome. Using AlphaGenome, we predicted the regulatory...
Jun Cheng, Kyle R. Taylor, Lauren Nicolaisen et al.· medRxiv· 3 citations· ⚡1
Results show that low-affinity motifs can be accurately mapped, shape the properties of developmental enhancers, and likely play a widespread role in fine-tuning enhancers during evolution.
Melanie Weilert, Kaelan J. Brennan, Khyati Dalal et al.· Cell Genomics· 1 citation
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