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Open access Oct 2026

SPAK regulates myocardial chloride homeostasis and drives dilated cardiomyopathy through mitochondrial dysfunction and energy metabolic disruption

Dilated cardiomyopathy (DCM) is a major cause of heart failure and sudden cardiac death, with myocardial ion homeostasis imbalance and mitochondrial dysfunction as core pathological mechanisms. However, the regulatory role of chloride (Cl⁻) homeostasis and its key mediators in DCM remains unclear. Ste20-related p...

S. Zhang, G. Li, Y. Wang et al. · 0 citations

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