Skeletal muscle tissue underlies several polygenic metabolic traits and diseases. Identifying their genetic mechanisms requires pinpointing cell types, regulatory elements, target genes and causal variants. Here we use genetic multiplexing to generate population-scale single-nucleus chromatin accessibility (single-nucl...
Arushi Varshney, Nandini Manickam, Peter Orchard et al.· Nature Genetics· 0 citations
Heart failure with preserved ejection fraction (HFpEF) represents a predominant heart failure phenotype characterized by intricate pathophysiology and an escalating global prevalence. Beyond classical hemodynamic disturbances, emerging evidence identifies mitochondrial dysfunction as a central mechanism in HFpEF pathog...
Ying An, Cong-Hui Shang, A. M. Abd el-Aty et al.· The Journal of Cardiovascula...· 0 citations
S-HFD is associated with gut dysbiosis and steatohepatitis-like features, highlighting the importance of fat sources in shaping microbiome-host interactions in metabolic disease.
F. Bahman, M. Z. Malik, S. Kochumon et al.· Frontiers in Nutrition· 0 citations
Together, the results reveal dysregulation in pathways in muscle tissue from individuals with diabetes, identify candidate drivers, and connect the genomic drivers of this dysregulation across type 2 diabetes and related metabolic traits.
A. Maddox, Nandini Manickam, Peter Orchard et al.· bioRxiv· 0 citations
It is suggested that sucrose elimination from a low-fat diet disrupts gut microbiota, impairs metabolic homeostasis, and promotes gut and liver inflammation, revealing an unrecognized dietary trigger of metabolic dysfunction.
N. Almansour, S. Kochumon, Fatema Al-Rashed et al.· Frontiers in Immunology· 0 citations
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