Background. Replicative aging of stem cells requires a mechanism counting cell divisions. Centrioles — organelles with mother–daughter asymmetry and no de novo generation in most somatic cells — are candidate division counters: their geometry may accumulate mitotic-age information.
Hypothesis. The centriole acts as a...
Objective: Peer review serves as the primary quality assurance mechanism in scholarly publishing, yet its capacity to forecast the downstream scientific impact of published research remains inadequately characterized. This study systematically reviews and meta-analyzes empirical evidence examining the association betwe...
It is hypothesized that centriole elimination, transient expression of totipotency factors, and de novo centriole assembly — “Eliminate, Reprogram, Rebuild” — recapitulate the germline cycle and may enable stable totipotency.
Somatic cell nuclear transfer succeeds (Wilmut et al., 1997) but depends on oocyte cytoplasm that has undergone natural centriole elimination. No method using transcription factors, small molecules, or culture conditions alone has produced sustained totipotency from a fully differentiated somatic cell—though transient...
