Author

Jaba Tqemaladze

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Open access Aug 2026

The Centriole as a Candidate Division Counter in Stem-Cell Aging

Background. Replicative aging of stem cells requires a mechanism counting cell divisions. Centrioles — organelles with mother–daughter asymmetry and no de novo generation in most somatic cells — are candidate division counters: their geometry may accumulate mitotic-age information. Hypothesis. The centriole acts as a...

Jaba Tqemaladze, MD · Longevity Horizon · 0 citations

Review Open access 2026

The Predictive Validity of Peer Review for Article Impact: A Systematic Review and Meta-Analysis

Objective: Peer review serves as the primary quality assurance mechanism in scholarly publishing, yet its capacity to forecast the downstream scientific impact of published research remains inadequately characterized. This study systematically reviews and meta-analyzes empirical evidence examining the association betwe...

Jaba Tqemaladze · Longevity Horizon · 0 citations

Open access Aug 2026

A Proposed Experimental Protocol for Testing Centriole-Mediated Somatic Totipotency Induction

It is hypothesized that centriole elimination, transient expression of totipotency factors, and de novo centriole assembly — “Eliminate, Reprogram, Rebuild” — recapitulate the germline cycle and may enable stable totipotency.

Jaba Tqemaladze, MD · Longevity Horizon · 0 citations

Open access Aug 2026

The Centriole as a Structural Ratchet That Restricts Cellular Reprogramming to Totipotency

It is predicted that centriole elimination combined with totipotency factors will yield stable, self-renewing totipotent cells, distinct from transient 8C-like cells.

Jaba Tqemaladze, MD · Longevity Horizon · 0 citations