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Author

Jacek Plewka

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Jul 2026

Discovery of natural product-derived rosavin as a programmed death-ligand 1 inhibitor for cancer immunotherapy.

Rosavin is identified as a privileged novel and unexpected scaffold for designing potent PD-1/PD-L1 modulators, offering promising candidates for cancer immunotherapy and exhibiting the unusual small-molecule property of inhibiting PD-L1 without inducing its dimerization.

Wei Zou, Tianle Li, Jacek Plewka et al. · 0 citations
Review Open access Jul 2026

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules

A comparative, structure-driven analysis of PD-L1 complexes deposited in the Protein Data Bank is presented and it is demonstrated that distinct inhibitory modalities converge on the same functional CC′FG hotspot region while employing fundamentally different neutralization mechanisms.

Imma Capriello, T. Moreira Pereira, Gustavo Barbosa Reis et al. · 0 citations
Jul 2026

Novel Selenium-Containing Small Molecule PD-L1 Inhibitors: Design, Synthesis, and Evaluation of the Antitumor Activity.

Cell-based assays showed that SA13 can mediate the internalization of PD-L1 and strongly block hPD-1 and hPD-L1 interaction, demonstrating its effectiveness in biological events and indicating that SA13 is a promising and safe novel antitumor agent worthy of further development.

Jianwei Wang, Shenwei Yu, Liang Qian et al. · 0 citations