Author

Jack Coomes

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Open access Oct 2026

NAD+ limitation and α-ketoglutarate depletion define cancer induced muscle atrophy

Tumour-host crosstalk is an emerging hallmark of malignancy. It is increasingly recognised that cancer alters non-tumour bearing distant organs, with important consequences for disease progression and survival. Skeletal muscle loss, a defining feature of cancer-associated cachexia, contributes to morbidity and reduced...

Vassilis Papalazarou, Jack Coomes, L. Rossi et al. · bioRxiv · 0 citations

Open access Oct 2026

Macrophage-induced ferritin expression protects pancreatic cancer cells from ferroptosis.

Reactive oxygen species (ROS) drive pro-tumorigenic signaling but also promote lipid peroxidation and ferroptosis, making ROS regulation critical during high oxidative stress stages of tumor progression, such as metastasis. Loss of the antioxidant TIGAR in pancreatic ductal adenocarcinoma (PDAC) cells raises ROS and en...

Eric C. Cheung, Meng-Han Wu, Wen-Chih Cheng et al. · Cell Reports · 0 citations