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Author

Jackson Champer

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Open access Aug 2026

Confinement considerations for CRISPR toxin-antidote gene drive systems

Gene drives are potentially powerful tools, able to spread throughout target populations. They could be used to modify or suppress disease vectors, invasive species, and agricultural pests. Yet, in many scenarios, confinement of the drive to only a target population is required. Several types of drives are capable of t...

Ziqian Xu, Yuna I. Cho, Xin-Yue Zhang et al. · 0 citations
Open access Jul 2026

Target site and guide RNA multiplexing architecture shape homing gene drive efficiency in Drosophila suzukii

It is found that using more than one gRNA reduced the efficiency of inheritance, especially in females, and this results show that gene drive performance depends strongly on biological context and design choices, and that strategies must be carefully optimized in the target species.

Amarish K. Yadav, Weizhe Chen, Jackson Champer et al. · 0 citations
Open access Aug 2026

Two-locus CRISPR toxin-antidote gene drive for confined population modification

2-locus TARE drives represent promising tools for effective and strongly confined population modification and are constructed with underdominance characteristics, yielding a higher introduction threshold even when drive performance is ideal.

Ruobing Feng, Andrea Y.N. Tan, Zhuoran Lu et al. · 1 citation

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