Author

Jacob A. Marsh

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Open access Sep 2026

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

Using isogenic human induced pluripotent stem cell-derived microglia carrying the pathogenic MAPT IVS10+16 mutation, tau is identified as a regulator of microglial lysosomal function and degradative capacity is identified as a modifiable component of the microglial response to tau pathology.

Kylie J. Schache, Rui Zhang, Audrey Street et al. · bioRxiv · 0 citations

Open access Jul 2026

Ms4a4a loss reprograms amyloid-associated microglia and limits dense-core plaque-associated tau spreading

These findings identify Ms4a4a as a regulator of plaque-associated microglial programs linked to NP-tau accumulation in the amyloid-bearing brain, which supports a model in which AD resilience-associated microglial pathways selectively shape plaque-associated microenvironments that promote downstream tau pathology.

E. Danhash, Shao-Yu Fang, Jacob A. Marsh et al. · bioRxiv · 0 citations

Open access Jul 2026

The NORAD-pumilio regulatory axis links lncRNA dysregulation to tau propagation-associated phenotypes

Findings identify widespread lncRNA dysregulation across neural cell types in the setting of a MAPT mutation and nominate the NORAD-pumilio axis as a regulatory pathway linking RNA homeostasis and tau propagation biology.

Joseph E. Zemke, Guangming Huang, Emma Starr et al. · bioRxiv · 0 citations