Abstract B016: MHC-II expressing pancreatic tumor cells alter macrophage polarization through VEGFA-NRP1 signaling
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immunotherapies. Tumor-associated macrophages (TAMs) represent a major cellular component of the TME and play a critical role in sustaining immunosuppres...