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Author

Jacopo Giuliani

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Review Open access Sep 2026

PAMORAs in Cancer and Non-Cancer Opioid-Induced Constipation: A Systematic Review, Meta-Analysis, and Personalized Value-Based Evaluation Integrating Clinical and Patient-Reported Outcomes

Background: Opioid-induced constipation (OIC) is a frequent and clinically relevant complication of long-term opioid therapy in both cancer and non-cancer populations, negatively affecting symptoms, treatment adherence, and health-related quality of life. Peripherally acting μ-opioid receptor antagonists (PAMORAs) repr...

F. Fiorica, Maria Viviana Candela, Jacopo Giuliani et al. · 0 citations

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