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Author

Jacques Crommen

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Jul 2026

Spatially Driven DNA-Based Probe Proximity Assay for Total Antibody Quantification in Antibody-Drug Conjugates.

This method reduces the recovery loss caused by decreased affinity from payload conjugation and delivers comparable signals for trastuzumab, T-DM1, and T-DXd, which provides a novel approach to address accuracy issues arising from affinity changes due to ADC dynamics in vivo.

Zhiwei Chen, Yu-Ling Liao, Ying Zhou et al. · 0 citations

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