Author

Jae-Il Park

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Open access Oct 2026

RhoA Y42C drives cell plasticity and PD-1-mediated immune evasion of diffuse gastric cancer

Diffuse gastric cancer (DGC) is an aggressive gastric cancer subtype with a poor prognosis. The RHOA Y42C mutation is recurrent in DGC, but its independent oncogenic role is unclear. Next-Generation Sequencing of 431 DGC cases revealed that most RHOA mutations occurred without CDH1 alterations. Using genetically engine...

Kyung-Pil Ko, Sangmin Kim, Jin-Ho Jang et al. · Nature Communications · 0 citations

Review Open access Oct 2026

Cell plasticity in cancer and therapy resistance.

Cancer cell plasticity, the ability of tumor cells to switch between distinct cellular states, has emerged as a key mechanism driving tumor progression, metastasis and therapy resistance. Cancer cells exploit diverse plasticity mechanisms, including dedifferentiation, transdifferentiation, epithelial-mesenchymal transi...

Yoojeong Seo, Jin-Ho Jang, Jae-Il Park · Experimental and Molecular M... · 0 citations