Jaehoon Sim

Discovery of novel pyrazolo[3,4-d]pyrimidine-6-amine derivatives as potent polo-like kinase 2 inhibitors.

Polo-like kinase 2 (PLK2), a serine/threonine kinase involved in cell cycle regulation, has emerged as a promising therapeutic target in cancer due to its role in tumor cell proliferation and survival. In this study, we report the design and synthesis of novel PLK2 inhibitors, featuring pyrazolo[3,4-d]pyrimidine deriva...