Open access
Sep 2026
Betaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury
Nuclear factor erythroid 2–related factor 2 (Nrf2) coordinates detoxification and antioxidant programs that protect the liver from chemical and metabolic stress. Nrf2 is restrained by Kelch-like ECH-associated protein 1 (Keap1), which can be removed through p62-mediated selective autophagy; however, nutritional cues th...
Moon-Han Chang, Chae Hwan Lee, Yeongrae Cho et al.
· Molecular Biomedicine · 0 citations