Heterogeneous structural and pathogenic properties of transthyretin dimeric variants.
Transthyretin amyloidosis (ATTR) is caused by the deposition of transthyretin (TTR) aggregates. While unstable TTR monomers, which are dissociated from the native tetramer, are known to be the primary amyloidogenic precursors of ATTR, the pathological role of other intermediates, such as dimers and oligomers, remains u...