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Author

Jaeyoung Lee

2 papers indexed here

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Sep 2026

Discovery of Novel GPR119 Agonists with Improved Kinetic Solubility and Drug-like Properties for Type 2 Diabetes Treatment

GPR119 is a compelling therapeutic target for type 2 diabetes due to its role in promoting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucose-dependent insulin secretion. This study aimed to develop a series of novel GPR119 agonists with exceptional kinetic solubility over a...

Jaeki Min, Jihun Kim, Kyeongwon Moon et al. · 0 citations
Open access Sep 2026

MT-Exo-derived miR-4651 and miR-6126 coordinately regulate the SRSF1-progerin and SP1-PrPᶜ axes to attenuate vascular aging in HGPS.

Hutchinson-Gilford progeria syndrome (HGPS) is characterized by progressive vascular injury that remains incompletely controlled by therapies targeting progerin-associated pathology. Here, we investigated the therapeutic activity and molecular mechanisms of melatonin-preconditioned mesenchymal stromal cell-derived smal...

E. Joo, Unyoung Yoon, Jaeyoung Lee et al. · 0 citations

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