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Jaidynne N. Lash

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Open access Sep 2026

The anti-leukemia drug ponatinib attenuates NLRP3 inflammasome activation in macrophages

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is an established driver of inflammation in diseases such as diabetes, Alzheimer's disease, and gout. Previously, we screened 875 FDA-approved drugs for NLRP3 inhibitors and identified ponatinib as one of the five candidates that reduced NLRP3...

Abigail H. Evered, Daniel C. Shippy, Jaidynne N. Lash et al. · 0 citations

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