Jair G. Marques

mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer

Changes in metabolomic profile in dogs with hepatic encephalopathy secondary to congenital portosystemic shunt suggests mitochondrial homeostasis disturbances.

Dogs with HE exhibit a different serum metabolomic profile compared to dogs without signs of HE, suggesting disturbances in mitochondrial homeostasis in dogs suffering from HE.

Intestinal bacteria hijack an evolutionarily conserved epithelial repair signal

Hypoxanthine is a potent promoter of epithelial cell repair in both gut and skin across the phylogenetic tree including humans, mice, zebrafish, and fruit flies and promotes similar ATP production and cellular proliferation in eukaryotic and microbial recipients.