Molecular basis of angiotensin-converting enzyme 1 selectivity of food-derived anti-hypertensive peptides.
Angiotensin converting enzyme 1 (ACE1) is a key regulator of the renin-angiotensin system. Given that the catalytic domains of the ACE homologs are highly similar, ACE1 inhibitory peptides may inadvertently interfere with ACE2, potentially disrupting RAS homeostasis. Here, we investigated the molecular basis of ACE1/AC...