James A. Carroll

Astrocytic Stat3 is dispensable for prion disease progression despite its role in neuroinflammation

Prion diseases are fatal proteinopathies caused by the misfolding of the host-derived prion protein, leading to neurodegeneration and neuroinflammation in the brain. Although prion disease has been extensively studied, the cellular pathways contributing to gliosis and neuronal loss remain incompletely understood. O...

Life at the interface: Byron Caughey’s search for prion disease inhibitors through chemistry, structure, and cell physiology