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Author

James J. Galligan

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2 papers indexed here

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Review Oct 2026

Non-enzymatic protein modifications at the interface of metabolism and immunity.

Immune cells are highly metabolically active throughout their life cycle, leading to elevated levels of a variety of reactive metabolites including reactive oxygen species, sugars, and lipid peroxidation products. These molecules covalently modify proteins, resulting in post-translational non-enzymatic covalent modific...

Nicola Walker, James J. Galligan, Y. David et al. · 0 citations
Open access Sep 2026

PHD Inhibitor Vadadustat: The First Drug Therapy for Triosephosphate Isomerase Deficiency

Background/Objectives: Triosephosphate isomerase deficiency (TPI Df) is an ultra-rare autosomal recessive glycolytic disorder characterized by symptoms of hemolytic anemia, progressive neuromuscular dysfunction, and early mortality. The TPI1E105D mutation (TPI1 variant p.Glu105Asp) accounts for most cases, though TPI D...

Emmanuel Scalais, Priyal S. Patel, Sidney L. Satterfield et al. · 0 citations

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