James M Roach

A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Beneficial and maladaptive opioid effects are difficult to dissociate, partly because dopamine signaling contributes to both. Here we show that associative opioid-reward learning can be blocked even under conditions that elevate dopamine in the nucleus accumbens. We developed naloxoneDART, a cell-type-specific analogue...