James M. Scherer

Structure and activity of the giant RNA polymerase ejected from Pseudomonas phage DEV.

A hallmark of Schitoviridae bacteriophages is a giant (∼3,500-residue) virion-associated RNA polymerase (vRNAP) that is ejected into the host to initiate early transcription. Structural and functional characterization of vRNAP has thus far been limited to coliphage N4, leaving the conservation of vRNAP architecture, pr...