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James R. Simmons

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Open access Sep 2026

Spatial genome organization in nematodes with programmed DNA elimination.

Programmed DNA elimination (PDE) is a notable exception to genome integrity. In many nematodes, PDE is initiated by DNA double-strand breaks (DSBs), leading to chromosome fragmentation and subsequent DNA loss. However, the mechanism of nematode programmed DNA breakage remains largely unclear. In the human and pig paras...

James R. Simmons, Tian-Chun Xue, R. P. McCord et al. · 0 citations

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