Open access
Jul 2026
Discovery of low molecular weight protein-binding fragments from bead-displayed libraries: application to monomeric proteins
Various strategies to multimerize monomeric targets are explored, thus allowing them to be used as targets in this fragment discovery platform and a particularly effective and convenient strategy is to express a fusion of the POI with FOLDON, a 30-residue, homo-trimeric peptide.
Joel Tong, Isuru M. Jayalath, James V. Parsons et al.
· RSC Chemical Biology · 0 citations