Author

Jamie H. D. Cate

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Open access Aug 2026

Enzymatic formation of a conserved isoaspartate in ribosomal protein uS11

Isoaspartate (isoAsp) formation is typically viewed as a “molecular clock” through nonenzymatic degradation of aspartate or asparagine during protein aging. Here we report a nearly universal enzymatic pathway for the formation of a conserved isoAsp in the bacterial ribosomal protein uS11. Proteome-wide protein-protein...

Yanqing Xue, Chandrima Majumdar, Salimat O. Sofela et al. · bioRxiv · 0 citations

Open access Sep 2026

Improving RNA Secondary Structure Prediction Through Expanded Training Data.

A large and diverse dataset comprising paired RNA sequences and their corresponding secondary structures is developed, and SincFold exhibited improved performance on a set of previously unseen RNA families, enhancing its capability to predict accurate de novo RNA secondary structures.

Conner J. Langeberg, Taehan Kim, Roma Nagle et al. · RNA: A publication of the RN... · 0 citations

Open access Jul 2026

Structure and evolution-guided design of minimal RNA-guided nucleases

A protein design strategy is used that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs, establishing a strategy for creating non-natural RNA-guided nucleases and conformatio...

Petr Skopintsev, Isabel Esain-Garcia, Evan C. DeTurk et al. · Science · 2 citations