Open access
Aug 2026
G-quadruplex DNA reprograms the photochemistry of CX-5461 toward radical-driven anticancer activity
In vivo, light-activated CX-5461 suppresses tumor growth and extends survival in immunocompetent syngeneic models, eliciting hallmarks consistent with immunogenic genome stress, and supporting a model in which broader oxidative DNA damage may also contribute to the biological response.
Jakub Trojnar, M. V. Cottini, Marta Dudek et al.
· Nucleic Acids Research · 0 citations