Sphingofungin-based aminopolyols and DIX-like azasugars - their synthesis and in vitro biological profile.
A simple stereodivergent approach to sphingofungin-based aminopolyols and their modification into 1,5-dideoxy-1,5-iminoxylitol (DIX)-based 1-N-iminosugars was accomplished. The use of a [3,3]-heterosigmatropic rearrangement on carbohydrate scaffolds, followed by Grubbs metathesis chemistry, provided an efficient route...