Author

Janet Chenevert

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Open access Aug 2026

Spatiotemporal regulation of LGN/NuMA and astral microtubules generate mirror symmetric spindle rotations

The positioning of the mitotic spindle controls the size, content, and position of daughter cells within embryos and tissues. A major spindle positioning mechanism is “cortical pulling” whereby the membrane-bound complex LGN/NuMA/Dynein captures astral microtubules and pulls centrosomes toward the cell cortex. Cytoplas...

Janet Chenevert, Anne Rosfelter, Daniel Gonzalez-Suarez et al. · bioRxiv · 0 citations

Open access Jul 2026

The extraordinary robustness of mitotic spindle assembly to microtubule dynamics plasticity revealed by end-binding proteins and tubulin tagging

This work reveals both the remarkable robustness of mitotic spindle assembly in response to extreme microtubule dynamics plasticity, and the requirement for strict control of microtubule dynamics across successive early embryonic divisions.

M. L. Robert, Aurélien Perrier, Janet Chenevert et al. · bioRxiv · 0 citations