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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

János M. Réthelyi

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2 papers indexed here

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Open access Oct 2026

KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathways

KCNQ1 encodes a voltage-gated potassium channel implicated in peripheral and neurological disorders, but its role in human neurodevelopment remains unclear. We generated KCNQ1 knockout (KO) human induced pluripotent stem cells and differentiated them into neural stem cells (NSCs) and cortical neurons. KCNQ1-deficient N...

Dorothea Schall, B. Guler, Siamand Alibrahim et al. · 0 citations
Open access Aug 2026

Beyond animal models: using human pluripotent stem cell-derived stem and progenitor cells to predict cytotoxicity in normal tissues

Background The clinical efficacy of anticancer drugs is often limited by dose-dependent toxicity to normal cells, particularly to rapidly dividing stem and progenitor cell populations. Traditional preclinical toxicity screening relies on animal models or primary human cells/immortalized lines, both of which have signif...

K. Vincze, N. Varga, Szilárd Tóth et al. · 0 citations

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