Author

Janosch Hennig

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Open access Aug 2026

Transient interdomain interactions shape the conformational ensemble governing RNA recognition by the tandem RRMs of Sex-lethal

RNA recognition motif (RRM) proteins frequently contain multiple RNA-binding domains connected by flexible linkers, yet the contribution of transient interdomain interactions to RNA recognition remains incompletely understood. Here, we investigated the structural organization of the tandem RRMs of the Drosophila melano...

Julia Meyer, Kristian Schweimer, P. Matzner et al. · bioRxiv · 0 citations

Review Open access Jul 2026

Integrative structural biology of protein-RNA interactions in four dimensions.

Recent developments in integrative modeling of protein-RNA complexes are reviewed, highlighting advances in in-cell, 4D and condensate structural biology, and how these approaches shape the understanding of RNP assembly, regulation, and function in physiologically relevant environments are discussed.

S. Heber, Janosch Hennig · Current Opinion in Structura... · 1 citation