Author

Jared L. Johnson

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Open access Sep 2026

Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.

High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged...

N. Tignor, M. Koptyra, Shrabanti Chowdhury et al. · Cell Reports Medicine · 0 citations

Jul 2026

Abstract B052: The Kinase Library: A global atlas of the human protein kinome and its applications in drug discovery

Mass-spectrometry-based phosphoproteomics now profiles phosphorylation at proteome scale, yet converting site-level measurements into coherent, kinase-centered biology — and into actionable drug discovery decisions — remains a persistent barrier to target nomination, mechanism-of-action confirmation, and resistance m...

Tomer M. Yaron-Barir, Jared L. Johnson, Lewis C. Cantley · Clinical Cancer Research · 0 citations

Jul 2026

An AI-enabled structural atlas decodes kinase specificity across the human proteome.

KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.

David Vanderwall, Edward L. Huttlin, J. Mintseris et al. · Nature Biotechnology · 0 citations