Open access
Sep 2026
Iterative and data-driven ortholog mining enables reliable discovery of stereoselective ketoreductases
Ketoreductases (KREDs) enable stereoselective alcohol synthesis and are widely used industrially. Yet identifying process-compatible and selective enzymes for non-native substrates remains challenging, requiring extensive screening. Here, we present an iterative ortholog mining strategy to explore functional space....
Peter Stockinger, M. Niklaus, Kevin M. Yar et al.
· Nature Communications · 0 citations