Author

Jason A. Papin

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Open access Sep 2026

Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

This work provides a systems-level computational framework linking transcriptomic alterations with predicted metabolic remodeling in GABAergic neurons and generates experimentally testable hypotheses regarding metabolic dysfunction during progression from MCI to AD.

Andrea Angarita-Rodríguez, Johan H. Largo-González, Julián Pérez-Mejía et al. · Frontiers in Systems Biology · 0 citations

Open access Aug 2026

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

[This corrects the article DOI: 10.3389/fbinf.2026.1816121.].

Andrea Angarita-Rodríguez, Viviana Vargas-López, Andrés Pinzón et al. · Frontiers in Bioinformatics · 0 citations

Open access Jul 2026

Integrating multi-omics data with network modeling to characterize Pseudomonas aeruginosa persister cell metabolism

This study reveals that persister cells retain active metabolism and exhibit a metabolic program distinct from that of untreated cells, and integrated transcriptomics, metabolomics, and genome-scale metabolic modeling to identify specific metabolic pathways that are critical for persister survival.

Joseph M. Ficarrotta, Anna S. Blazier, Aline Métris et al. · Journal of Bacteriology · 0 citations