Jason Lucavs

CDKL5 deficiency impairs TBK1-mediated autophagy and clearance of neuronal protein aggregates

The clearance of unwanted protein aggregates is essential for maintaining proteostasis and cellular function, particularly in long-lived cells such as neurons, yet the signaling pathways that activate selective autophagy of protein aggregates remain incompletely understood. Here, we identify the neurodevelopmental kina...